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26 OCTOBER 2014

Donald Norman: The Research-Practice Gulf

"There is a great gulf between the research community and practice. Moreover, there is often a great gull between what designers do and what industry needs. We believe we know how to do design, but this belief is based more on faith than on data, and this belief reinforces the gulf between the research community and practice.

I find that the things we take most for granted are seldom examined or questioned. As a result, it is often our most fundamental beliefs that are apt to be wrong.

In this talk, deliberately intended to be controversial. I examine some of our most cherished beliefs. Examples: design research helps create breakthrough products; complexity is bad and simplicity good; there is a natural chain from research to product."



2010abstract models • applied social science • appropriately complex representationbreakthrough innovation • breakthrough products • call to actionChicagocomplexitydesign and innovationdesign communitydesign conferencedesign practicedesign research • design research conference • designer-centred designdisruptive innovationdogmaDonald Normanethnographic design approach • existing product categories • failure of design research • fundamental beliefs • generalised modelsHCDhuman-centred designideation • IIT Institute of Design (ID) • Illinois Institute of Technology (IIT) • incremental innovationinnovation process • innovative breakthroughs • keynote address • product developmentradical innovationrapid prototypingreal-world designreal-world projectsresearch communityresearch-practice gulf • results-driven • simplicitytesting perpetuates mediocrity • translational engineering • translational sciencewhat designers do • what industry needs


Simon Perkins
18 DECEMBER 2013

Imperial College London: Personalised Healthcare

"Many pharmaceuticals have idiosyncratic action when administered. The concept that healthcare solutions can be tailored to the individual is one that is attractive as it potentially allows a better match of patient and drug.

Identifying signatures indicative of treatment outcome are key to personalising medicine. Top–down systems biology offers an opportunity to help predict drug efficiacy and avoid adverse reactions.

Providing optimised healthcare on an individual basis will benefit both patients and clinicians through improved drug choice, efficacy and reduced costs. From the work we have conducted using large scales molecular epidemiology studies using metabolic phenotyping, it is clearer than ever before that a one–size–fits–all solution to drug therapy is not a sustainable or desirable model. Given the diversity of human biochemistry, such phenotypes are important in personalising medicine as they provide clues as to the influences of a variety of factors including underlying genetics, environmental stress, nutritional status and gut microbial activity."



biological diversityclinical medicine • Computational and Systems Medicine (CSM) • digital health • drug choice • drug efficiacy • drug therapy • environmental stress • epidemiology • evidence-based healthcare • gene signature • genetic signatures of diseases • gut microbial activity • healthcare research • healthcare solutions • human biochemistry • human health • idiosyncrasies • idiosyncratic action • individualised healthcare • interdisciplinary research • metabolic phenotyping • molecular epidemiology • molecular epidemiology studies • nutritional status • one-size-fits-all solution • optimised healthcare • patient carepersonalised healthcare • personalising medicine • pharmaceutical drugs • pharmaceuticals • phenotypes • primary healthcare research • scientific research • systems biology approaches • translational medicine • translational science • underlying genetics • wellbeing


Simon Perkins

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