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18 DECEMBER 2013

Imperial College London: Personalised Healthcare

"Many pharmaceuticals have idiosyncratic action when administered. The concept that healthcare solutions can be tailored to the individual is one that is attractive as it potentially allows a better match of patient and drug.

Identifying signatures indicative of treatment outcome are key to personalising medicine. Top–down systems biology offers an opportunity to help predict drug efficiacy and avoid adverse reactions.

Providing optimised healthcare on an individual basis will benefit both patients and clinicians through improved drug choice, efficacy and reduced costs. From the work we have conducted using large scales molecular epidemiology studies using metabolic phenotyping, it is clearer than ever before that a one–size–fits–all solution to drug therapy is not a sustainable or desirable model. Given the diversity of human biochemistry, such phenotypes are important in personalising medicine as they provide clues as to the influences of a variety of factors including underlying genetics, environmental stress, nutritional status and gut microbial activity."

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TAGS

biological diversityclinical medicine • Computational and Systems Medicine (CSM) • digital health • drug choice • drug efficiacy • drug therapy • environmental stress • epidemiology • evidence-based healthcare • gene signature • genetic signatures of diseases • gut microbial activity • healthcare research • healthcare solutions • human biochemistry • human health • idiosyncrasies • idiosyncratic action • individualised healthcare • interdisciplinary research • metabolic phenotyping • molecular epidemiology • molecular epidemiology studies • nutritional status • one-size-fits-all solution • optimised healthcare • patient carepersonalised healthcare • personalising medicine • pharmaceutical drugs • pharmaceuticals • phenotypes • primary healthcare research • scientific research • systems biology approaches • translational medicine • translational science • underlying genetics • wellbeing

CONTRIBUTOR

Simon Perkins
24 SEPTEMBER 2013

Inside Out of Mind: ethnographic research catalyst for theatre project

"Based on extraordinary and extensive ethnographic research, Inside Out of Mind offers moving insight into the mysterious domain of dementia; a world of medical magical realism peopled with puppets and performers in pursuit of a lost man in pursuit of lost love. A darkly comic and empathic tale."

(Meeting Ground Theatre Company)

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TAGS

Anna Mottram • arts and sciencesdementiadissemination through performanceethnographic researchethnographically informed study • Health Care Assistant (HCA) • healthcare • Holly-Robyn Harrison • hospital treatment • hospital wards • Inside Out of Mind (play) • Jarrod Cooke • Jim Findley • Joanna Macleod • Joanne Lloyd • Justine Schneider • Kezia Scales • Lakeside Arts Centre (Nottingham) • Lily Lowe-Myers • Maurice Roeves • Maxine Finch • medical research • Meeting Ground (theatre company) • NHS • no name • Nottinghamnursepatient carereality as processresearch disseminationresearch project • Sean Myatt • Simon Bailey • Tanya Myers • theatre • theatre company • theatre projectstheatrical performancetheatrical playtrauma • Ulrike Johannson

CONTRIBUTOR

Simon Perkins
29 JUNE 2013

The (UK) National Institute for Health Research

"The mission of the National Institute for Health Research (NIHR) is to maintain a health research system in which the NHS supports outstanding individuals, working in world class facilities, conducting leading edge research focused on the needs of patients and the public. ...

Since its establishment in April 2006, the NIHR has worked with key partners involved in the different elements of NHS research to transform research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy and developed and supported the people who conduct and contribute to applied health research."

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TAGS

2006 • applied health research • basic science • clinical medicineclinical researchDepartment of Healthhealth • health research • leading edge research • medical practicemedical research • National Institute for Health Research • NHS • NIHR • patientpatient care • patient needs • primary careresearch • Research for Patient Benefit • research funding • RfPB • Sally Davies • tangible benefits • UK

CONTRIBUTOR

Simon Perkins
01 NOVEMBER 2012

What is the Liverpool Care Pathway?

"The Liverpool Care Pathway (LCP) is a scheme that is intended to improve the quality of care in the final hours or days of a patient's life, and to ensure a peaceful and comfortable death. It aims to guide doctors, nurses and other health workers looking after someone who is dying on issues such as the appropriate time to remove tubes providing food and fluid, or when to stop medication.

However, its use for some has become controversial, with relatives reportedly claiming it has been used without consent, and some saying it is used inappropriately.

This criticism and the media emphasis on the supposed controversy is puzzling, as the LCP has been standard practice in most hospitals for a number of years. The LCP has also received recognition on both a national and international level as an example of good practice.

As a GP put it in the British Medical Journal, the LCP 'has transformed end of life care from an undignified, painful experience into a peaceful, dignified death at home'"

(NHS Choices, UK)

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TAGS

1990s • advanced illness • British Medical Journal • care • comfortable death • consent • controversydeath • death pathway • diedignitydyingemotional needsend of life • end of life care • end-of-life careeuthanasiagood practiceGPguide • health workers • healthcare • hospice • hospital • LCP (acronym) • life • Liverpool Care Pathway • Marie Curie Palliative Care Institute • media criticism • medication • multidisciplinary approach • National Health Service • NHS • palliative care • patientpatient care • peaceful • physical needs • plan of care • prolonging life • public health • quality of care • relieve suffering • Royal Liverpool University Hospital • social needs • spiritual needs • suffering • terminally ill • UK • undignified

CONTRIBUTOR

Simon Perkins
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