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18 DECEMBER 2013

Imperial College London: Personalised Healthcare

"Many pharmaceuticals have idiosyncratic action when administered. The concept that healthcare solutions can be tailored to the individual is one that is attractive as it potentially allows a better match of patient and drug.

Identifying signatures indicative of treatment outcome are key to personalising medicine. Top–down systems biology offers an opportunity to help predict drug efficiacy and avoid adverse reactions.

Providing optimised healthcare on an individual basis will benefit both patients and clinicians through improved drug choice, efficacy and reduced costs. From the work we have conducted using large scales molecular epidemiology studies using metabolic phenotyping, it is clearer than ever before that a one–size–fits–all solution to drug therapy is not a sustainable or desirable model. Given the diversity of human biochemistry, such phenotypes are important in personalising medicine as they provide clues as to the influences of a variety of factors including underlying genetics, environmental stress, nutritional status and gut microbial activity."

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TAGS

biological diversityclinical medicine • Computational and Systems Medicine (CSM) • digital health • drug choice • drug efficiacy • drug therapy • environmental stress • epidemiology • evidence-based healthcare • gene signature • genetic signatures of diseases • gut microbial activity • healthcare research • healthcare solutions • human biochemistry • human health • idiosyncrasies • idiosyncratic action • individualised healthcare • interdisciplinary research • metabolic phenotyping • molecular epidemiology • molecular epidemiology studies • nutritional status • one-size-fits-all solution • optimised healthcare • patient carepersonalised healthcare • personalising medicine • pharmaceutical drugs • pharmaceuticals • phenotypes • primary healthcare research • scientific research • systems biology approaches • translational medicine • translational science • underlying genetics • wellbeing

CONTRIBUTOR

Simon Perkins
29 JUNE 2013

The (UK) National Institute for Health Research

"The mission of the National Institute for Health Research (NIHR) is to maintain a health research system in which the NHS supports outstanding individuals, working in world class facilities, conducting leading edge research focused on the needs of patients and the public. ...

Since its establishment in April 2006, the NIHR has worked with key partners involved in the different elements of NHS research to transform research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy and developed and supported the people who conduct and contribute to applied health research."

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TAGS

2006 • applied health research • basic science • clinical medicineclinical researchDepartment of Healthhealth • health research • leading edge research • medical practicemedical research • National Institute for Health Research • NHS • NIHR • patientpatient care • patient needs • primary careresearch • Research for Patient Benefit • research funding • RfPB • Sally Davies • tangible benefits • UK

CONTRIBUTOR

Simon Perkins
28 APRIL 2011

Narrative techniques in medicine: tagging / indexing narratives

"There are a number of ways in which text–based narrative content can be synthesized and analyzed to generate more quantitatively oriented findings. Common approaches involve attaching descriptors like tags (keywords) or indexes (retrieving concepts) or extracting thematic patterns as 'codes' (commonalities). The content author or a researcher can manually code content by looking for recurring ideas or subjects, or use Internet tools to attach tags to narrative content. One system developed by 'Cognitive Edge' applies semi–structured tagging to narrative content to generate 'numerical data with rich context' (Snowden)."

(Eleanor Herriman, p.3–4)

Fig.1 James 's Public Gallery [https://picasaweb.google.com/ilmainstreetleaders] 'People broke up into small groups to share personal health care stories. Stephanie Arnet and her daughter, Satwant and Onkar Dhillon and Debbie Miller.'

2). Eleanor Herriman (2008). 'Narrative Techniques in Medicine: Translating Cognitive Sciences into Potent Informatics Instruments', Vol. 3 No. 1 April 2008 Medical Informatics Review, IC Sciences Corp.

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TAGS

analysisannotationclinical medicine • code content • codes • cognitive potency • cognitive profiling • commonalities • Dave Snowden • descriptors • evaluation instruments • evaluation methods • extracting thematic patterns • healthcare • indexes • indices • internet tools • keyword tags • keywords • medical informatics • medicine needs narrative • narrative • narrative as personal expression • narrative as story • narrative content • natural language processingnew technologies • NLP • numerical data with rich context • open-ended questionspersonal narrativesquantitatively oriented findingsrecurring ideas • recurring subjects • researcher • retrieving concepts • semi-structured tagging • storysynthesistaggingtags • text-based narrative content • thematic analysisthematic patterns

CONTRIBUTOR

Simon Perkins
20 MARCH 2011

General Practice Notebook: an online medical encyclopaedia

"GPnotebook is a concise synopsis of the entire field of clinical medicine focussed on the needs of the General Practitioner.

The database is continually being updated by a team of authors. We take a pragmatic approach to authoring: we look out for topical issues, keep track of the journals and update material in response to user feedback.

We use a range of knowledge sources, including clinical experience, knowledge taken from literature reviews, original research articles and guidelines published by national and international bodies. In many cases references are made to sources of information; we are committed to making GPnotebook fully referenced in the near future. As a team we review each other's work but we also rely in the feedback from experts in primary care and the various clinical specialities to keep us on the right track.

Our editorial decisions are based on merit and are not influenced by any funding bodies.

We make every effort to ensure that the contents of the site are correct however we cannot be held responsible for any errors or ommissions."

(Oxbridge Solutions Ltd., UK)

TAGS

body • clinical • clinical medicinedatabasediagnosisdiseasedoctorencyclopaediaexpert knowledge • general practitioner • GP • GP Notebook • guidelineshealthhuman patientsillnessinformationinjuryknowledge baseknowledge repositorymedicalmedical practice • medical reference • medical researchnotebook • online encyclopaedia • operationpainpractitioner • prevention • primary care • prognosis • public healthreferencerepositoryresearch findingssearchsearch enginesexual healthsufferingtherapytreatmentUK

CONTRIBUTOR

Simon Perkins
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