"Many pharmaceuticals have idiosyncratic action when administered. The concept that healthcare solutions can be tailored to the individual is one that is attractive as it potentially allows a better match of patient and drug.
Identifying signatures indicative of treatment outcome are key to personalising medicine. Top–down systems biology offers an opportunity to help predict drug efficiacy and avoid adverse reactions.
Providing optimised healthcare on an individual basis will benefit both patients and clinicians through improved drug choice, efficacy and reduced costs. From the work we have conducted using large scales molecular epidemiology studies using metabolic phenotyping, it is clearer than ever before that a one–size–fits–all solution to drug therapy is not a sustainable or desirable model. Given the diversity of human biochemistry, such phenotypes are important in personalising medicine as they provide clues as to the influences of a variety of factors including underlying genetics, environmental stress, nutritional status and gut microbial activity."
"The mission of the National Institute for Health Research (NIHR) is to maintain a health research system in which the NHS supports outstanding individuals, working in world class facilities, conducting leading edge research focused on the needs of patients and the public. ...
Since its establishment in April 2006, the NIHR has worked with key partners involved in the different elements of NHS research to transform research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy and developed and supported the people who conduct and contribute to applied health research."
"There are a number of ways in which text–based narrative content can be synthesized and analyzed to generate more quantitatively oriented findings. Common approaches involve attaching descriptors like tags (keywords) or indexes (retrieving concepts) or extracting thematic patterns as 'codes' (commonalities). The content author or a researcher can manually code content by looking for recurring ideas or subjects, or use Internet tools to attach tags to narrative content. One system developed by 'Cognitive Edge' applies semi–structured tagging to narrative content to generate 'numerical data with rich context' (Snowden)."
(Eleanor Herriman, p.3–4)
Fig.1 James 's Public Gallery [https://picasaweb.google.com/ilmainstreetleaders] 'People broke up into small groups to share personal health care stories. Stephanie Arnet and her daughter, Satwant and Onkar Dhillon and Debbie Miller.'
2). Eleanor Herriman (2008). 'Narrative Techniques in Medicine: Translating Cognitive Sciences into Potent Informatics Instruments', Vol. 3 No. 1 April 2008 Medical Informatics Review, IC Sciences Corp.
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